Arginine Pyroglutamate (APG)

Fri May 19 12:17:44 CDT 2006

Growth Hormone . . . Is It All Hype?

The combination of arginine pyroglutamate and lysine makes a very effective GH releaser.
A study published in 1981 used a special form of arginine (arginine pyroglutamate), in combination with lysine (another amino acid), to induce a significant GH release when taken orally in relatively small amounts. Fifteen healthy male subjects, aged 15 to 20 years old, were given 1,200 mg of arginine pyroglutamate combined with 1,200 mg of L-lysine hydrochloride. The results of this specific combination were spectacular, causing a large GH release that was sustained for several hours. (Abstract)

This breakthrough paper has often been misquoted and discounted, as several other researchers failed to replicate the results.

Unfortunately, these subsequent researchers used arginine hydrochloride and NOT arginine pyroglutamate, which was used with great results in the original study in 1981. This is disappointing, as it had been known since 1977 that the specific chelate of arginine and pyroglutamic acid (arginine pyroglutamate) had effects on the body that are not shared by arginine or pyroglutamic acid when taken individually or together.

No nutritional supplement has shown equivalent results to the combination of arginine pyroglutamate and lysine for releasing significant amounts of biologically active GH when taken orally in small doses. Interestingly, when both arginine pyroglutamate and lysine are taken individually, even in large doses, they are not effective.16 It is the specific combination of arginine pyroglutamate and lysine, taken in the proper ratio, which makes a very effective GH releaser.

UCLA Nobelist found that the amino acid L-arginine and the anti-oxidants Vitamins C and E with moderate exercise reduced the development of atherosclerosis, or hardening of the arteries, in mice that are genetically prone to heart disease. (Read More)


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